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(3) RESEARCH STUDIES REGARDING THE EFFECTS OF BERES DROPS PLUSŪ ON THE IMMUNE SYSTEM

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|| Stimulates Interleukin 6 || || Increases Certain Cells || || Enchances Endocrine Function of Thymus || ||Glucocorticoid receptors (gcR) increased in peripheral lymphocytes || ||More Research Studies || || Our Other Products ||

Biol Trace Elem Res 1996 Mar;51(3):293-301

A trace element preparation containing zinc increases the production of interleukin-6 in human monocytes and glial cells.

Falus A, Beres J Jr Department of Biology, Semmelweis Medical University, Budapest, Hungary.

The in vitro effects of a trace element preparation (beres Drops Plus, BDP) on the biosynthesis of inflammatory cytokines interleukin (IL-6, IL-1, and tumor necrosis factor-alpha (TNF-alpha) were studied in human peripheral monocytes. The production of IL-6 was studied in a glioblastoma cell line, SKMG-4, as well. The trace element preparation BDP significantly stimulated both the constitutive and the endotoxin or IL-1 induced IL-6 production in monocytes or in glial cells, respectively, but revealed no or only modest effect on IL-1 and TNF-alpha production of monocytes. Moreover, BDP was able to reduce the inhibitory effect of a synthetic corticosteroid, dexamethasone on the biosynthesis of IL-6. The positive effect of the trace element preparation on the IL-6 production of monocytes from rheumatoid arthritis (RA) patients is comparable, to that of on the monocytes from healthy individuals, and similarly to healthy individuals was negligible on the IL-1 and TNF-alpha production. The detailed analysis of the composition of the preparation suggested, that the major active component in the stimulation of IL-6 production is Zn, but for the complete effect other trace elements are also required.

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Lik Sprava 1995 May;5-6:133-135

The mechanism of the immunomodulating action of Beres Drops Plus.

[Article in Russian] Grinevich IuA, Bendiug GD

Beres Drops Plus were found to raise the number of E-RFCs, being formed by lymphocytes of peripheral blood of subjects presenting with low levels of T-cells, and to increase the production of substances possessing thymosine-like activity (STLA) by lymphocytes and epithelial cells of the murine thymus gland. In vitro the drug preparation in question enhances endocrine function of thymus in normal animals and the organism's capacity to induce STLA synthesis following thymectomy. These findings are useful in devising rational schemes of rehabilitation of immune system with the drug preparation Beres Drops Plus in secondary immunodeficiency states developing in cases presenting with precancer conditions, malignant neoplasia, in those subjects having taken part in the elimination of the Chernobyl NPP accident aftermath, those residing on the territories controlled, as well as evolving on account of aging.

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Acta Microbiol Immunol Hung 1995;42(3):271-275

The number of glucocorticoid receptors in peripheral human lymphocytes is elevated by a zinc containing trace element preparation.

Falus A, Beres J Jr Department of Biology, Semmelweis University Medical School, Budapest, Hungary.

A trace element preparation (Beres Drops Plus, BDP) elevates the number of glucocorticoid receptors (gcR) in peripheral lymphocytes isolated both from healthy blood donors and rheumatoid arthritis patients. This enhancement by BDP was found either for constitutive expression of gcRs or in experiments when the lymphocytes were stimulated by interleukin (IL)-6. There was no significant effect of BDP on IL-1 and tumour necrosis factor alpha (TNF alpha)-induced changes of gcRs. The effect of BDP was greatly dependent on the presence of Zn++ ions in the preparation, since the augmenting effect was abolished if BDP did not contain zinc.

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